APPLICABILITY OF MALDI-ORBITRAP-MS FOR THE EARLY DIAGNOSIS OF RENAL CELL CARCINOMA BASED ON THE LIPIDOMIC ANALYSIS OF BLOOD AND URINE SAMPLES

摘要

Renal cell carcinoma (RCC) is the most common type of kidney cancer. The RCC incidence and the mortality rate have been increasing globally during the last decade. Up to date, there are still no recommended screening tests for early diagnosis. In our work, the matrix-assisted laser desorption/ionization coupled with Orbitrap mass spectrometry (MALDI-Orbitrap-MS) is used for the clinical study of patients with RCC and healthy volunteers.