FACTOR XA ANTICOAGULANT BIOACTIVE PROTEINS DERIVED FROM SCORPION VENOM

摘要

Of the 1400 species of scorpions worldwide [1], the Chinese scorpion is used in Chinese medicines for cardiovascular problems [2], antimicrobial [3], and tumors [4]. The venom is a complex mixture of proteins containing bioactive components [5], some showing inhibition of enzyme factor Xa, which prevents blood coagulation [6]. These proteins are often modified and crosslinked with multiple disulphide bonds, with only partial genome sequences, therefore requiring de novo sequencing.