首页> 外国专利> BITORAN WHICH IS TRYPSIN-INHIBITOR-LIKE PROTEIN DERIVED FROM BITIS ARIETANS VENOM, AND USE THEREOF AS BLOOD COAGULATION FACTOR Xa INHIBITOR

BITORAN WHICH IS TRYPSIN-INHIBITOR-LIKE PROTEIN DERIVED FROM BITIS ARIETANS VENOM, AND USE THEREOF AS BLOOD COAGULATION FACTOR Xa INHIBITOR

机译：BITORAN是一种胰蛋白酶-抑制剂类似蛋白，是从比比斯定植的蛇毒中提取的，并将其用作血凝因子Xa抑制剂

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摘要

The present invention provides a novel Kunitz-type inhibitor protein exhibiting high potency to inhibit serine protease activity of human blood coagulation factor Xa. The Kunitz-type inhibitor protein against human blood coagulation factor Xa according to the present invention isa Kunitz-type inhibitor protein: bitoran D from Bitis arietans venom having the following amino-acid sequence I:; <TableGroup align="left" colSep="0" cols="2" rowSep="0"> <Colspec align="right" colName="1" colWidth="217pt"/> <Colspec align="left" colName="2" colWidth="0pt"/> <Tbody valign="top"> <Row> <entry>(SEQ ID NO:1)</entry> <entry/> </Row> </Tbody> </TableGroup> </TableFormula> <TableFormula> <Title/> <TableGroup align="left" colSep="0" cols="2" rowSep="0"> <Colspec align="left" colName="1" colWidth="217pt"/> <Colspec align="left" colName="2" colWidth="0pt"/> <Tbody valign="top"> <Row> <entry>SKKRP DFCYL PADDG PCRAF IPSFY YNSTS NECNT FIYGG</entry> <entry/> </Row> <Row> <entry/> </Row> <Row> <entry>CYGNA NKFES MDECR KTCVA SA,</entry> </Row> </Tbody> </TableGroup> </TableFormula> </Table> <UnorderedList id="ul0003" listStyle="none"> <ListItem id="ul0003-0001" number="0000"> <UnorderedList id="ul0004" listStyle="none"> <ListItem id="ul0004-0001" number="0000">a Kunitz-type inhibitor protein: bitoran V from <I>Bitis arietans </I>venom having the following amino-acid sequence II:</ListItem> </UnorderedList> </ListItem> </UnorderedList> ; <Table id="TABLE-US-00002"> <TableFormula> <Title/> <TableGroup align="left" colSep="0" cols="2" rowSep="0"> <Colspec align="right" colName="1" colWidth="217pt"/> <Colspec align="left" colName="2" colWidth="0pt"/> <Tbody valign="top"> <Row> <entry>(SEQ ID NO:2)</entry> <entry/> </Row> </Tbody> </TableGroup> </TableFormula> <TableFormula> <Title/> <TableGroup align="left" colSep="0" cols="2" rowSep="0"> <Colspec align="left" colName="1" colWidth="217pt"/> <Colspec align="left" colName="2" colWidth="0pt"/> <Tbody valign="top"> <Row> <entry>C RQNRP DFCYL PAVEG PCRAY IRSFF YNSTS NECEK FFYGG</entry> <entry/> </Row> <Row> <entry/> </Row> <Row> <entry>CYGNA NKFET RDECR KTCVA SA,</entry> </Row> </Tbody> </TableGroup> </TableFormula> </Table>or a modified protein thereof. </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span>本发明提供了表现出高抑制人凝血因子Xa的丝氨酸蛋白酶活性的新的Kunitz型抑制剂蛋白。根据本发明的针对人凝血因子Xa的Kunitz型抑制剂蛋白是<UnorderedList id =“ ul0001” listStyle =“ none”> <ListItem id =“ ul0001-0001” number =“ 0000”> <UnorderedList id =“ ul0002” listStyle =“ none”> <ListItem id =“ ul0002-0001” number =“ 0000”>一种Kunitz型抑制剂蛋白：来自<I> Arietans </ I>毒液的bitoran D，具有以下氨基酸序列I：</ ListItem> </ UnorderedList> </ ListItem> </ UnorderedList >; <Table id =“ TABLE-US-00001”> <TableFormula> <标题/> <TableGroup align =“ left” colSep =“ 0” cols =“ 2” rowSep =“ 0”> <Colspec align =“ right” colName =“ 1” colWidth =“ 217pt” /> <Colspec align =“ left” colName =“ 2” colWidth =“ 0pt” /> <Tbody valign =“ top”> <行> <entry>（SEQ ID NO：1）</ entry> <entry /> </ Row> </ Tbody> </ TableGroup> </ TableFormula> <TableFormula> <标题/> <TableGroup align =“ left” colSep =“ 0” cols =“ 2” rowSep =“ 0”> <Colspec align =“ left” colName =“ 1” colWidth =“ 217pt” /> <Colspec align =“ left” colName =“ 2” colWidth =“ 0pt” /> <Tbody valign =“ top”> <行> <entry> SKKRP DFCYL PADDG PCRAF IPSFY YNSTS NECNT FIYGG </ entry> <entry /> </ Row> <行> <entry /> </ Row> <行> <entry> CYGNA NKFES MDECR KTCVA SA，</ entry> </ Row> </ Tbody> </ TableGroup> </ TableFormula> </ Table> <UnorderedList id =“ ul0003” listStyle =“ none”> <ListItem id =“ ul0003-0001” number =“ 0000”> <UnorderedList id =“ ul0004” listStyle =“ none”> <ListItem id =“ ul0004-0001” number =“ 0000”>一种Kunitz型抑制剂蛋白：来自<I> Arietans </ I>毒液的Bitoran V，具有以下氨基酸序列II：</ ListItem> </ UnorderedList> </ ListItem> </ UnorderedList> ; <Table id =“ TABLE-US-00002”> <TableFormula> <标题/> <TableGroup align =“ left” colSep =“ 0” cols =“ 2” rowSep =“ 0”> <Colspec align =“ right” colName =“ 1” colWidth =“ 217pt” /> <Colspec align =“ left” colName =“ 2” colWidth =“ 0pt” /> <Tbody valign =“ top”> <行> <entry>（SEQ ID NO：2）</ entry> <entry /> </ Row> </ Tbody> </ TableGroup> </ TableFormula> <TableFormula> <标题/> <TableGroup align =“ left” colSep =“ 0” cols =“ 2” rowSep =“ 0”> <Colspec align =“ left” colName =“ 1” colWidth =“ 217pt” /> <Colspec align =“ left” colName =“ 2” colWidth =“ 0pt” /> <Tbody valign =“ top”> <行> <entry> C RQNRP DFCYL PAVEG PCRAY IRSFF YNSTS NECEK FFYGG </ entry> <entry /> </ Row> <行> <entry /> </ Row> <行> <entry> CYGNA NKFET RDECR KTCVA SA，</ entry> </ Row> </ Tbody> </ TableGroup> </ TableFormula> </ Table>或其修饰的蛋白质。 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33">著录项</h2> <div class="getdents"> <ul> <li> <p><span>公开/公告号</span><span>US2009036647A1</span></p> <p><span>专利类型</span><span></span></p> </li> <li> <p><span>公开/公告日</span><span>2009-02-05</span></p> <p><span>原文格式</span><span>PDF</span></p> </li> <li> <div class="apply"> <p><span style="width: 90px;display: inline-block;">申请/专利权人</span><span id="patentee" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=12_13&sertext=TAKASHI MORITA&option=232">TAKASHI MORITA;</a> </span></p> <span class="designer hoverxs" style="display: none;">展开▼</span> </div> <p><span>申请/专利号</span><span style="width: 250px;">US20050916621</span></p> </li> <li> <div class="apply"> <p><span style="width: 90px;display: inline-block;">发明设计人</span><span id="patentee" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=12_13&sertext=TAKASHI MORITA&option=202">TAKASHI MORITA;</a> </span></p> <span class="designer hoverxs" style="display: none;">展开▼</span> </div> <p><span>申请日</span><span>2005-06-06</span></p> </li> <li> <p style="width: 100%;"><span>分类号</span><span style="width: 80%;">C07K14/435;</span> </p> </li> <li> <p style="width: 100%;"><span>国家 </span><span style="width: 93%;">US</span></p> </li> <li><p style="width: 100%;"> <span >入库时间</span> <span>2022-08-21 19:30:27</span></p> </li> </ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity"> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul > <li >专利</li> <li >外文文献</li> <li >中文文献</li> </ul> </div> <div class="similarity_details"> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061201730802.html">胰蛋白酶样丝氨酸蛋白酶抑制剂,它们的制备以及作为凝结因子IIa和Xa的选择性抑制剂的用途</a> <b>[P]</b> . <span> 中国专利： CN103403018B </span> <span> . 2015.08.19</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120102172096.html">胰蛋白酶样丝氨酸蛋白酶抑制剂,它们的制备以及作为凝结因子IIa和Xa的选择性抑制剂的用途</a> <b>[P]</b> . <span> 中国专利： CN103403018A </span> <span> . 2013-11-20</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130434884789.html">BITIS ARIETANS SNAKE VENOM-DERIVED TRYPSIN INHIBITOR-LIKE PROTEIN BITORAN AND USE THEREOF AS INHIBITOR OF BLOOD 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Bin-Bin Zhang Wei-Min Cai Hong-Lei Weng Zhong-Rong Hu Jun Lu Min Zheng Rong-Hua Liu Institute of Infectious Diseases First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 Zhejiang Province China</a> <span> <a href="/journal-cn-52914/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 世界胃肠病学杂志：英文版 </a> </span> <span> . 2003</span><span>,第11期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_world-journal-gastroenterology-english_thesis/0201294496886.html">Effect of interleukin-10 and platelet-derived growth factor on expressions of matrix metalloproteinases-2 and tissue inhibitor of metalloproteinases-1 in rat fibrotic liver and cultured hepatic stellate cells</a> <b>[J]</b> <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Li-JuanZhang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Li-JuanZhang</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Yun-XinChen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Yun-XinChen</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Zhi-XinChen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Zhi-XinChen</a> <span> <a href="/journal-cn-52914/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 世界胃肠病学杂志：英文版 </a> </span> <span> . 2004</span><span>,第17期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-18152_thesis/020221966030.html">一种半夏胰蛋白酶抑制剂对大鼠胃功能的影响</a> <b>[C]</b> <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=王厚伟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王厚伟</a> <span> <a href="/conference-cn-18152/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第七届全国中医药生物化学与分子生物学学术交流会 </a> <span> <span> . 2008</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020312068998.html">大豆中抗营养因子脲酶和胰蛋白酶抑制剂不同测定方法的比较</a> <b>[A] </b> <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=卢晓凌&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 卢晓凌</a> <span> . 2008</span> </span> </div> </li> </ul> </div> </div>  </div> </div> </div> </div> <div class="right "> </div> </div> <div id="thesis_down_palent" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="xz('06130430522872','13',6,1,this,'9999',0)" title="专利原文即时下载到本机" prompt="0101301">获取专利</div> <span id="06130430522872down" data-source="6," data-out-id="US7505815B2," data-f-source-id="6" data-title="BITORAN WHICH IS TRYPSIN-INHIBITOR-LIKE PROTEIN DERIVED FROM BITIS ARIETANS VENOM, AND USE THEREOF AS BLOOD COAGULATION FACTOR Xa INHIBITOR" data-price="20" data-transnum="0" style="display:none;"></span> <div 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