WASTEWATER-BASED EPIDEMIOLOGY: USE OF ADULTERANTS TO ESTIMATE COCAINE CONSUMPTION PATTERNS IN BRASILIA, BRAZIL BY LC-QTOF-MS

摘要

Illicit drugs are a major public safety problem in Brazil. Findings of the Brazilian Federal Police concerning drug seizures show that levamisole (LEV) is the main adulterant in cocaine hydrochloride (mean of 13.2%),while phenacetin (PHE) is the mainly found in freebase cocaine - crack (mean of 15.2%). Thus, strategies based on quantification of LEV and PHE, together with the major cocaine metabolite, benzoylecgonine (BE), in wastewater may contribute to identify different forms of the consumed cocaine.