MODAFIENDZ METABOLITES IDENTIFICATION BY MEANS OF LC-HRMS: FROM IN SILICO PREDICTION TO IN VITRO CONFIRMATION WITH RAT HEPATOCYTES

摘要

New psychoactive substances (NPS) represent a tough challenge, since analytical standards are not available or included in libraries [1]. When metabolic pathway is unknown, determine target analytes is critical, so metabolites identification become fundamental for clinical and forensic investigations [2]. The aim of this work was to identify the metabolites of Modafiendz, a synthetic nootropic [3].