POST-COLUMN IN-SOURCE DERIVATIZATION IN LCMS: A TOOL FOR NATURAL PRODUCTS CHARACTERIZATION AND METABOLOMICS

摘要

Metabolite characterization is crucial for many aspects of basic research, such as de-replication of crude extracts in natural products chemistry or tentative identification in untargeted metabolomics. This information makes the subsequent decision-making process easier and more efficient. Derivatization with hydrazines is a known method in this respect, which allows the characterization of carbonyl functional groups [1-2].