GC-MS/MS DETERMINATION OF CIS AND TRANS-Δ9-THC ISOMERS IN CANNABIS SATIVA L

摘要

Hemp (Cannabis sativa L.)is a complex plant able to produce many chemical entities. Its biomedical relevance has-been focused on Δ9-tetrahydrocannabinol (Δ9-THC) (1). Anyway Δ9-THC exists in two geometrical isomers: cis and trans. The trans-Δ9-THC is the active compound responsible for the narcotic action of hemp. The existence and the distribution of the cis isomer in cannabis is still unclear (2). Aim of this study was the determination of the cis and trans-Δ9-THC in cultivar of Cannabis belonging to different chemotypes.