Highly sensitive analysis of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol in hair by micro-pulverized extraction and liquid chromatography/tandem mass spectrometry

摘要

The sample preparation using micro-pulverized extraction is very simple and LC/MS/MS is easier to use than GC/MS/MS in NICI which requires the ion source replacement, the waiting time to stabilize the instrument, and the proper derivatization for highly sensitive detection of THC-COOH. This method would be used as the first choiceforthe analysis of THC-COOHin hair.