Validated LC-MS/MS method for the determination of enantiomeric purity of S-Amlodipine in human plasma: Application to pharmacokinetic study.

摘要

This method was used to perform a comparative study of the pharmacokinetics of amlodipine 10mg and S-Amlodipine 5mg. The results revealed that the pharmacokinetic profile of S-amlodipine was comparable to that following the administration of the racemic mixture.