Ultra High Performance LC-QTOF workflow for Multi-Residue Pesticide Screening using Diagnostic Ion Enhanced Confirmation Criteria

摘要

The combination of True Isotopic Pattern (TIP) and fragmentation ions on a Ultra-High Performance LC-QTOF system has enabled an enhanced confirmation criteria for pesticide residue detection to be established. This in turn enables unprecedented levels of false positive detection rates of pesticide residues at the current European Union MRL in complex samples at mass resolution 20,000 to 30,000 FWHM. The successful application of a novel screening and quantitation software tool to simplify data processing is key to the facile deployment of this high resolution, accurate mass screening workflow.