High Resolution IMS-MS and UHPLC-HRMS for the analysis of natural products and complex natural extracts

摘要

This study demonstrates that isomeric flavonoids can be better resolved by IMS-MS compared to UPLC-MS. Moreover, a significant number of compounds were detected by direct analysis of the fungal extracts using IMS-MS and were not detected by UHPLC-MS or MS only. These results suggest that high resolution IMS is well suited for the separation of isomeric natural compounds (even in high-throughput metabolomics studies) and appears as an attractive alternative to established UHPLC-MS methods.