Development of Un-targeted Screening Method for Detection of Synthetic PDE-5 Inhibitors and Analogues Adulterated in Health Supplements on LCMS-IT-TOF

摘要

An un-targeted screening method for detection of adulterated PDE-5 inhibitor drugs and analogues in health supplements was developed on LCMS-IT-TOF with MetID Solution program. The method was proven to be effective for thirty-two compounds spiked in five different health supplement products randomly selected from local market. The detection reliability was evaluated with focusing on the matrix effect and peak interference. The results indicate that matrix effect is a key factor for the large variation in compositions of different samples due to their different recipes and materials used. A general detection limit of the screening method is proposed to be 0.5ppm based the evaluation performed in this study.