Analysis of Potential Genotoxic Impurities (PGI) in Active Pharmaceutical Ingredients (API) by GCMS/MS

机译：通过GCMS / MS分析活性药物成分（API）中的潜在遗传毒性杂质（PGI）

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A highly sensitive and selective method was developed for PGI's like sulfonic acid esters by using Shimadzu GCMS-TQ8040. Developed MRM method can be used for screening and quantification of sulfonic esters in various Pharmaceutical products. Ultra Fast scanning, UFsweeper and ASSP features enabled sensitive, selective and reproducible method of analysis.

机译：通过使用Shimadzu GCMS-TQ8040，为PGI的磺酸酯开发了高敏感和选择性方法。开发的MRM方法可用于筛选和定量各种药物产品中的磺酸酯。超快速扫描，UFSWEEPER和ASSP功能使能敏感，选择性和可重复的分析方法。

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2016年|1CD|共1页
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Prashant Hase; Ankush Bhone; Durvesh Sawant; Dheeraj Handique; Sanket Chiplunkar; Ajit Datar; Jitendra Kelkar; Pratap Rasam;
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中图分类 TB994.5-53;
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3. Control and analysis of alkyl and benzyl halides and other related reactive organohalides as potential genotoxic impurities in active pharmaceutical ingredients (APIs). [J] . Elder DP, Lipczynski AM, Teasdale A Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2008,第3期

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4. Analysis of Potential Genotoxic Impurities (PGI) in Active Pharmaceutical Ingredients (API) by GCMS/MS [C] . Prashant Hase, Ankush Bhone, Durvesh Sawant, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：通过GCMS / MS分析活性药物成分（API）中的潜在遗传毒性杂质（PGI）
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机译：采用电喷雾电离的LC / MS / MS低含量测定恩曲他滨活性药物成分中的甲磺酸甲酯和甲磺酸乙酯杂质

Analysis of Potential Genotoxic Impurities (PGI) in Active Pharmaceutical Ingredients (API) by GCMS/MS

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