Fast Analysis Workflow with No Sample Preparation for Forensic Applications using Open Probe Fast GC/MS: Unit and High Resolution MS

摘要

Fast sample analysis for identification of drugs in bulk samples (powder, solid, liquid) was demonstrated using unit resolution and accurate mass spectrometers. In addition to drug identification, the fast analysis allows for the determination of relative content within a sample such as in a Vicodin pill (powder sample). The fast analysis did not require sample preparation and allowed for a simple workflow to expedite screening in a forensics application and included the following steps: 1) run blank, 2) run sample, (3) run blank and (4) run standard for confirmation. This analysis workflow resulted in overall screening and confirmation (when running a standard) of <5 minutes for target analysis of drugs. Using a high resolution accurate mass Q-TOF, it can be expanded to non-targets and emerging targets as well. It can also be expanded to other fields that require fast screening and identification such as homeland security and organic synthesis.