ROUTINE MONITORING OF N-GLYCANS USING A NOVEL LABELING REAGENT WITH FLUORESCENCE AND MASS DETECTION

摘要

RapiFluor-MS labeled glycans demonstrate dramatically improved fluorescence and mass spectrometric properties for small neutral to large charged glycans Improved mass detection allows detectors such as the QDa to provide valuable mass information when added to current HILIC-FLR workflows. Ease of use of the QDa permit its use in high throughput analytical environments where mass information allows for faster decision making. Rapid sample preparation together with rapid analysis has the potential to significantly reduce the analytical burden of labs tasked with high throughput glycan analysis.