Development of the Ultra-Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method for Insulin Lispro

机译：胰岛素LISPRO超敏液相色谱 - 串联质谱法的发展

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A robust, high sensitivity, high throughput bioanalytical method for insulin lispro was developed and validated. Immunocapture afforded a clean extract and an LLOQ of 17.2 pM from a small sample volume. Assay throughput increased with the use of a monolithic column. The procedure should fulfill the requirements for most PK and TK studies of insulin and its analogs

机译：开发并验证了胰岛素LISPRO的稳健性，高敏感性，高通量生物分析方法。免疫抑制得到了清洁的提取物和17.2μm的LLOQ，来自小样品体积。测定产量随着整体柱的使用而增加。该程序应满足胰岛素及其类似物的大多数PK和TK研究的要求

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2015年||共1页
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Xiaodong Zhu; Tom Lloyd; Jingguo Hou; Jerry Gardella; Edward Wells; Steve Unger;
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中图分类 TB994.5-53;
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Development of the Ultra-Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method for Insulin Lispro

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