Use of QTRAP Mass Spectrometry in Cytochrome P450 (CYP450) Reaction Phenotyping of Bupropion

摘要

1. CYP2C19, for the first time, was identified as contributing to bupropion metabolism through several hydroxylation pathways at clinically relevant concentrations. 2. The new QTRAP method allows for rapid metabolite identification with simultaneous quantification, which provides more definitive reaction phenotyping information earlier in drug discovery.