Compound 48/80, a Mast Cell Degranulator, Induces Oxidative Stress in Rat Livers

摘要

We examined whether compound 48/80 (C48/80), a mast cell degranulator, induces oxidative stress in rat livers. Fasted male Wistar rats were injected with C48/80 (0.75 mg/kg, i.p), Increases in hepatic lipid peroxide, total ascorbic acid (AA), reduced AA, and oxidized AA levels and a decrease in hepatic reduced glutathione level occurred 3 h after C48/80 treatment. Hepatic gly-cogen level decreased 3 and 6 h after C48/80 treatment, Hepatic vitamin E level was not changed by C48/80 treatment. When vitamin E (200 mg/kg) was orally administered to C48/80-treated rats at 0,5 h after the treatment, all these changes found at 3 h after the treatment were almost completely attenuated. These results indicate that C48/80 induces oxidative stress in rat livers through an increase in hepatic AA synthesis associated with glutathione depletion.