Antitumorigenic role of BTB14431 and Emodin in the treatment of colonic cancer

摘要

High amount of side effects of new anti-tumorogenic agents, low efficacy or high costs impede their clinical use. Emodin and BTB14432 are new inhibitors of angio-genesis. Methods: 120 Wag-Rj rats were dealed with 105 CC531 colonic carcinoma cells intraperitoneally (ip) and subcutanously (sc). For the intravenous (iv) treatment a jugularis vein port catheter was implanted. First treatment was performed at operation's end. All rats were treated twice a day for one week with BTB 14431 and Emodin. Animals were sacrificed 28 days after therapy's end. Results: We showed a downward trend of the total tumor growth after iv treatment with the lowest BTB14431-dosis and emodin. Tumor load among the ip treated animals including the control group was lower than among the iv treated.