DETERMINATION OF ARTEMISININ BY HPLC WITH ON-LINE PHOTOREACTOR AND PEROXYOXALATE CHEMILUMINESCENCE DETECTION

摘要

Artemisinin (Fig. 1), isolated in 1972 from Chinese medicinal plant Artemisia annua L, is a novel antimalarial drug with a sesquiterpene lactone structure containing an internal endoperoxide linkage which is essential for the drug's activity. Artemisinin and its derivatitives form a series of antimalarial compounds with activity against chloroquine-resistant malaria parasites. In contrast to chloroquine, artemisinin penetrates the blood brain barrier, which makes it especially valuable for the treatment of cerebral malaria.1