Amphiphilic Poly (ε -caprolactone)-Chitooligosaccharide-Poly (ethylene glycol) (PCL-g-COS-g-PEG) Micelles for Drug Delivery: ?. Synthesis and Micelle Characterization

摘要

A new biodegradable amphiphilic copolymer, PCL-g-COS-g-PEG, was synthesized which could form micelles with the existence of free amine groups of COS for delivery gene or drugs. After the copolymer grafted with RGD tri-peptide, the propidium iodine (PI) encapsulated PCL-g-COS- g-PEG-RGD micelles showed much better in targeting HUVEC compared PCL-g-PEG micelles in vitro study.