Methotrexate　　encapsulated polymeric micelles of chitosan copolymer grafted with methoxy poly(ethylene glycol) and preparation method thereof

摘要

The present invention is a sustained release, such as the methoxy polyethylene glycol is improved stability of methotrexate to normal cells is directed to a polymeric micelle and a method of manufacturing the methotrexate is supported on a graft copolymer of chitosan. ; According to the present invention, the easily-methoxy polyethylene glycol to folic acid (folate) antineoplastic substance methotrexate without structural change can be supported on the grafted chitosan copolymer and and that improves the sustained release of methotrexate, for the normal cell reduce the toxicity may be useful to increase the efficacy of methotrexate. ; Water-soluble chitosan, methotrexate, polymeric micelles, methoxy polyethylene glycol