Bioactive Porous Bone Scaffold Coated with Biphasic Calcium Phosphates

摘要

Calcium phosphates (CaP) were coated on a zirconia (Z1O2) porous scaffold for hard tissue applications. The Z1O2 porous body, intended to be a load-bearing part, was fabricated by a polymeric foam reticulate method. On the framework, CaP layers were deposited by a powder slurry method to induce bioactivity and osteoconductivity. The compositions of the coating layers were varied to be biphasic, i. e., hydroxyapatite (HA) with tricalcium phosphate (TCP) and fluorapatite (FA). The coated scaffolds had a porosity of - 90 % and pore size of-500-600 urn. The compressive strength of the coated Z1O2 scaffolds was ~5 MPa, which was ~7 times higher than those of pure HA. The coating layers had a thickness of ~30 m and was firmly adhered to the substrate. The adhesive strength of the coating layer was -20-25 MPa. Human osteoblast-like cells grew and proliferated well on the coated scaffolds. The differentiation of the cells on the coated scaffolds was higher than those on pure Z1O2 scaffold, confirming improved cellactivity via the calcium phosphate coatings.