首页> 外文会议>International Symposium on Atherosclerosis >Rho and smooth muscle cell phenotypeNathalie F. Worth, Barbara E. Rolfe, Julie H. Campbell,
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Rho and smooth muscle cell phenotypeNathalie F. Worth, Barbara E. Rolfe, Julie H. Campbell,

机译:rho和平滑肌细胞蜂蜜细胞anathalie f. forth,barbara E. rolfe,朱莉H.坎贝尔,

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This study determined the influence of Rho in regulating phenotype in early passage rabbit aortic smooth muscle cell (SMC) culture.Extended confluence and serum-deprivation induced SMC differentiation, indicated by increased expression of contractile markers (a-SM actin, SM-MHC and SM-2). Activation of Rho by sphingosine-1 -phosphate (S-l-P) further enhanced the expression of contractile proteins and their reorganisation such that cells adopted a more 'contractile' phenotype Inhibition of Rho induced an extreme 'synthetic' morphology including increased vimentin expression.
机译:该研究确定了Rho在早期通过兔主动脉细胞(SMC)培养中调节表型的影响。扩建汇合和血清剥夺诱导的SMC分化,提高了收缩标记的表达(A-SM actin,SM-MHC和SM-MHC SM-2)。通过鞘氨醇-1-磷酸(S-L-P)激活rhO进一步增强了收缩蛋白的表达及其重组,使得细胞采用了更多的“收缩”表型抑制Rho诱导极端的“合成”形态,包括增加的Vimentin表达。

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