Catalytic Asymmetric C-C Bond Formation with Chiral Ruthenium Amido Complexes

摘要

Well-defined 16-electron chiral Ru amido complexes,Rut(S,S)-diamine](eta~6-arene),efficiently catalyze asymmetric Michael additions of 1,3-dicarbonyl compounds to nitroalkenes to give the Michael adducts in high yields and with excellent ee's.Malonates,beta-ketoesters,or 1,3-diketones as Michael donors react with nitroalkenes in toluene containing the Ru amido catalyst (S/C = 50-100) to afford the Michael adducts in up to 99% yield and with up to 98% ee.The outcome of the reaction was delicately influenced by the structures of the diamine and arene ligands as well as reaction conditions.