Asymmetric Protonation of Silyl Enolates Catalyzed by Chiral Phosphine-Silver(I) Complexes

摘要

A catalytic asymmetric protonation of trimethylsilyl enolates was achieved using BINAP-silver(I) fluoride complex as a chiral catalyst in a mixed solvent consisting of dichloromethane and methanol. Various nonracemic ketones possessing a tertiary asymmetric carbon at the a-position were prepared with high enantioselectivity up to 99% ee.