Asymmetric protonation of silyl enolates catalyzed by chiral phosphine-silver(l) complexes

摘要

A catalytic asymmetric protonation of trimethylsilyl enolates was achieved using a 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP)-silver(I) fluoride complex as a chiral catalyst in a mixed solvent consisting of dichloromethane and methanol.Various nonracemic ketones possessing a tertiary asymmetric carbon at the alpha-position were prepared with high enantioselectivity up to 99 % ee.