Rhodium-Catalyzed Arylation of Ketones, Imines, and Nitriles Using Arylboron Compounds

摘要

The rhodium-catalyzed nucleophilic addition reactions of organoboron and -stannane reagents to carbon-heteroatom multiple bonds are now recognized to be highly useful tools for C-C bond formation. In these reactions, the mild, weakly nueleophilic organometallic reagents are effectively activated under rhodium catalysis to react with aldehydes and activated imines possessing electron-withdrawing groups, such as sulfonyl substituents, on their nitrogen (Eq. 1). However, in contrast to the intermolecular additions toward the reactive electrophiles, those to ketones, unactivated imines, and nitriles have been considered to be sluggish.