First thromboemboiic Onset In Children carrying either the heterozygeous Factor V G16911 Mutation or the Prethrembin G20210A Variant

摘要

Disorders of the hemostatic system are major causes of thrombophilia in adults. Various genetic defects in the regulation of blood coagulation and fibrinolysis predispose to thromboemboiic events [1-5]. The factor V (FV) G1691A mutation and the prothrombin (FII) G20210A variant appear to be relevant not only in adult thromboembolism. However, due to the low incidence of thromboemboiic events in childhood, the role of hereditary prothrombotic risk factors is still a matter of discussion [6-12]. There is still a lack of data concerning the exogenous triggering factors associated with a first thromboemboiic event. Furthermore, a significantly higher incidence of thrombosis - especially renal venous thrombosis - in male neona-tes and infants compared to females has been described [13-15]. Therefore, a possible impact of age and gender on thromboemboiic manifestations in pediatric patients is of interest.