Influence of the factor II G20210A variant or the factor V G1691A mutation on symptomatic recurrent venous thromboembolism in children: an international multicenter cohort study.

Young G; Becker S; During C; Friedrichs F; Goldenberg N; Kenet G; Manco-Johnson M; Scheffold C; Nowak-Gottl U

首页> 外文期刊>Journal of thrombosis and haemostasis: JTH >Influence of the factor II G20210A variant or the factor V G1691A mutation on symptomatic recurrent venous thromboembolism in children: an international multicenter cohort study.

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Influence of the factor II G20210A variant or the factor V G1691A mutation on symptomatic recurrent venous thromboembolism in children: an international multicenter cohort study.

机译：II型G20210A因子变体或V G1691A突变对儿童有症状的复发性静脉血栓栓塞的影响：一项国际多中心队列研究。

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OBJECTIVE: To determine the relative importance of the factor (F) II G20210A or FV G1691A mutations as risk factors or predictors for fatalon-fatal recurrent venous thromboembolism (VTE) in children. METHODS: In the present cohort, the rate of VTE recurrence and the time to recurrence in relation to FII, FV, age, and sex was determined in consecutively enrolled patients with VTE aged newborn to

机译：目的：确定因子（F）II G20210A或FV G1691A突变作为儿童致命/非致命性复发性静脉血栓栓塞症（VTE）的危险因素或预测因子的相对重要性。方法：在本研究中，连续入选18岁以下携带FII的VTE新生儿的VTE复发率和复发时间与FII，FV，年龄和性别有关。 64）或FV（n = 194）突变。 158例无血栓形成的VTE患儿作为对照。随访患者中位数58个月。跨参与站点汇总数据，以增强功能并增强数据的通用性。发生率以每1000人年的事件数表示。结果：在416名儿童中，有44名在VTE发作后的中位12个月内复发了VTE。复发的总发生率为19.8，FII变异患者为57.9，FV携带者为17.9，对照组为11.8。在比较FII患者时，FV儿童和经过年龄和性别校正的对照队列多变量分析（Cox回归）显示FII变异（危险比2.6; 95％置信区间1.1-5.9）影响了复发性VTE的危险。结论：基于多变量分析，FII变异的存在与VTE复发风险增加相关。

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《Journal of thrombosis and haemostasis: JTH》 |2009年第1期|共8页
作者
Young G; Becker S; During C; Friedrichs F; Goldenberg N; Kenet G; Manco-Johnson M; Scheffold C; Nowak-Gottl U;
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正文语种 eng
中图分类临床医学;
关键词
Child; Recurrence; cohort; Thromboembolism; Mutation; 儿童; 复发; 血栓栓塞; 突变;

机译：Child;Recurrence;cohort;Thromboembolism;Mutation;儿童;复发;血栓栓塞;突变;

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1. Influence of the factor II G20210A variant or the factor V G1691A mutation on symptomatic recurrent venous thromboembolism in children: an international multicenter cohort study. [J] . Young G, Becker S, During C, Journal of thrombosis and haemostasis: JTH . 2009,第1期

机译：II型G20210A因子变体或V G1691A突变对儿童有症状的复发性静脉血栓栓塞的影响：一项国际多中心队列研究。
2. Factor V Leiden (G1691A) and prothrombin gene G20210A mutations as potential risk factors for venous thromboembolism after total hip or total knee replacement surgery. [J] . Wahlander K, Larson G, Lindahl TL, Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 2002,第4期

机译：因子V Leiden（G1691A）和凝血酶原基因G20210A突变是全髋关节置换术或全膝关节置换术后静脉血栓栓塞的潜在危险因素。
3. Coagulation factor V G1691A, factor II G20210A and methylenetetrahydrofolate reductase C677T gene mutations do not play a major role in symptomatic neonatal arterial ischaemic stroke [J] . Arnaez Juan, Arca Gemma, Martin-Ancel Ana, British Journal of Haematology . 2018,第2期

机译：凝血因子V G1691A，因子II G20210A和甲基四乙烯醇还原酶C677T基因突变在症状新生儿动脉缺血性中风中不起作用主要作用
4. First thromboemboiic Onset In Children carrying either the heterozygeous Factor V G16911 Mutation or the Prethrembin G20210A Variant [C] . A. Kosch, S. Becker, K:~Kurnik, Hemophilie-Symposion . 2003

机译：携带杂合因子V G16911突变或妊娠期G20210A变体的第一次血栓发病
5. Risk and protective factors influencing children at risk for overweight and obesity in low-income, single female, primary caregiver households: An exploratory qualitative study. [D] . Lappan, Sara N. 2016

机译：影响低收入，单身女性，主要照料家庭中有超重和肥胖风险的儿童的风险和保护因素：一项探索性定性研究。
6. Factor V Leiden G1691A and prothrombin G20210A mutations among Palestinian patients with sickle cell disease [O] . Fekri Samarah, Mahmoud A. Srour 2000

机译：巴勒斯坦镰状细胞病患者中的V因子Leiden G1691A和凝血酶原G20210A突变
7. Avaliação da incidência das mutações G1691A no gene do fator V (fator V Leiden) e G20210A no gene da protrombina em pacientes com diabetes mellitus tipo 2 Incidence of G1691A factor V gene (factor V Leiden) and G20210A prothrombin gene mutations in type 2 diabetes patients [O] . Anna L. Soares, Marinez O. Sousa, Marcelo C. Lasmar, 2005

机译：2型糖尿病患者中凝血酶V基因（凝血因子V Leiden）和G20210A基因G1691A突变发生率的评估在2型糖尿病患者中凝血酶V基因（凝血因子V Leiden因子）和G20210A凝血酶原基因突变的发生率

Influence of the factor II G20210A variant or the factor V G1691A mutation on symptomatic recurrent venous thromboembolism in children: an international multicenter cohort study.

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