FABRICATION OF A μ-SCALE HIGH THROUGHPUT PLATFORM FOR HIGH DENSITY GENE EXPRESSION AND GENOTYPING APPLICATIONS

摘要

DNA microarrays have helped to reshape and expand the fields of genetics and molecular biology. Their uses span the spectrum of applications from academic research, clinical / point-of-care diagnostics, pathogen detection and drug discovery. These applications define a diverse set of requirements for supporting technologies, including automated systems for processing hundreds of samples in parallel through rugged integrated devices compatible with field testing. We have developed a robust platform for parallel processing of 96 high density arrays which can serve as a model for the development of μ-scale integrated devices without compromise of data quality or density.