SMART DISPOSABLE PLASTIC LAB-ON-A-CHIP FOR POINT-OF-CARE TESTING (POCT)

摘要

This paper presents the development of smart, disposable biochip for point-of-care testing (POCT) applications. The key features of the biochip include: integrated metallic microneedle for sampling, smart passive microfluidic control system, integrated on-chip air bursting detonators for fluidic driving and biosensor array for analyzing clinically relevant parameters from human blood. An on-chip calibration solution pouch is also included, allowing dispensing of a known concentration calibration buffer. The use of calibration solution cancels out interfering signals from external environment such as temperature variations. The biochip performance has been characterized and the fully-integrated biochip has been used to successfully monitor Glucose, Lactate, and Oxygen concentration from human blood .