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Point-of-care testing (POCT) diagnostic systems using microfluidic lab-on-a-chip technologies

机译:使用微流体芯片实验室技术的即时检验(POCT)诊断系统

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摘要

Point-of-care testing (POCT) is necessary to provide a rapid diagnostic result for a prompt on-site diagnosis and treatment. A quick analysis time and high sensitivity, with a sample-to-answer format, are the most important features for current POCT diagnostic systems. Microfluidic lab-on-a-chip technologies have been considered as one of the promising solutions that can meet the requirement of the POCT since they can miniaturize and integrate most of the functional modules used in central laboratories into a small chip. This review covers recent advances in POCT technologies with an emphasis on demonstrated and commercially available POCT diagnostic systems with laboratory quality using microfluidic lab-on-a-chip technologies. As working principles and required functional modules depend on target analytes, we categorize the applications of the POCT diagnostic systems according to the analyte types such as proteins, cells, nucleic acids, and metabolites. In each analyte category, detection methods, configuration of POCT lab-on-a-chip modules, and advantages and disadvantages of POCT systems are reviewed and discussed along with future prospects.
机译:即时检验(POCT)对于快速诊断结果以进行迅速的现场诊断和治疗是必不可少的。快速的分析时间和高灵敏度以及从样品到答案的格式,是当前POCT诊断系统最重要的功能。微流体片上实验室技术被认为是可以满足POCT要求的有前途的解决方案之一,因为它们可以将中央实验室中使用的大多数功能模块小型化并集成到一个小芯片中。这篇综述涵盖了POCT技术的最新进展,重点是使用微流体芯片实验室技术的具有实验室质量的经过验证的商用POCT诊断系统。由于工作原理和所需功能模块取决于目标分析物,因此我们根据分析物类型(例如蛋白质,细胞,核酸和代谢物)对POCT诊断系统的应用进行分类。在每种分析物类别中,都会对POCT片上实验室模块的检测方法,配置以及POCT系统的优缺点进行回顾和讨论,并展望未来。

著录项

  • 来源
    《Microelectronic Engineering》 |2015年第1期|46-57|共12页
  • 作者单位

    Microsystems and BioMEMS Laboratory, University of Cincinnati, Cincinnati, OH 45221, USA,Center for Applied NanoBioscience and Medicine, University of Arizona, Chandler, AZ 85226, USA;

    Siloam Biosciences Inc, Cincinnati, OH 45240, USA;

    School of Electrical Engineering and Computer Science, Louisiana State University, Baton Rouge, LA 70803, USA;

    Microsystems and BioMEMS Laboratory, University of Cincinnati, Cincinnati, OH 45221, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Point-of-care testing (POCT); Microfluidic lab-on-a-chip technologies; Sample-to-answer;

    机译:即时检验(POCT);微流体芯片实验室技术;样品到答案;
  • 入库时间 2022-08-18 01:27:00

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