Inhibition of Renin Angiotensin Aldosterone System,and Insulin-Like Growth Factor-1 Axis and Physical Performance

摘要

Observational studies have shown that the use of angiotensin-converting enzyme (ACE) inhibitors (ACEIs) is associated with the maintenance of higher muscle strength and physical performance in older persons free of chronic heart failure. There is evidence of a direct role exerted by ACE-inhibitor treatment on parameters of physical performance, but the exact mechanism underlying the effects of ACEIs remains poorly understood. Since ACEIs block the production of Angiotensin II, which is a potent inhibitor of insulin-like growth factor-1 (IGF-1), it is conceivable that there is a relationship between ACEIs administration and serum IGF-1 levels. Decline of IGF-1 with age is also associated with poor muscle mass and strength.The link between ACE inhibitors or other medications inhibiting renin angiotensin aldosterone system, physical performance and IGF-1 will be analyzed in this review.