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The Swarming Body: Simulating the Decentralized Defenses of Immunity

机译:蜂拥而至:模拟免疫的分散防御

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We consider the human body as a well-orchestrated system of interacting swarms. Utilizing swarm intelligence techniques, we present our latest virtual simulation and experimentation environment, IMMS:VIGO::3D, to explore key aspects of the human immune system. Immune system cells and related entities (viruses, bacteria, cytokines) are represented as virtual agents inside 3-dimensional, decentralized and compartmentalized environments that represent primary and secondary lymphoid organs as well as vascular and lymphatic vessels. Specific immune system responses emerge as by-products from collective interactions among the involved simulated 'agents' and their environment. We demonstrate simulation results for clonal selection and primary and secondary collective responses after viral infection, as well as the key response patterns encountered during bacterial infection. We see this simulation environment as an essential step towards a hierarchical whole-body simulation of the immune system, both for educational and research purposes.
机译:我们认为人体是一个策划的互动群体系统。利用群体智能技术,我们展示了我们的最新虚拟仿真和实验环境,IMMI:Vigo :: 3D,探讨人类免疫系统的关键方面。免疫系统细胞和相关实体(病毒,细菌,细胞因子)在三维,分散和分区化环境中表示为虚拟试剂,其代表初级和次级淋巴器官以及血管和淋巴管。特定的免疫系统反应从涉及模拟的“代理商”及其环境中的集体相互作用中出现副产品。我们证明了病毒感染后克隆选择和初级和二次集体反应的仿真结果,以及在细菌感染期间遇到的关键反应模式。我们将此模拟环境视为朝着教育和研究目的的免疫系统分层全身模拟的重要步骤。

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