Miraziridine A:a three-in-one protease inhibitor

摘要

Miraziridine A (Fig.1) is a natural product from the marine sponge THheonella aff.mirabilis that has been recently isolated and structurally elucidated [1].Among the great variety of protease inhibitors from natural sources,this tetrapeptide seems to be unique because it unifies within one molecule three structural elements:1) (2R,3R)-aziridine-2,3-dicarboxylic acid ii) statine,and iii) vinylogous arginine which constitutes per se or as fragments known cysteine,aspartyl,and serine protease inhibitors.