First total synthesis of omphalotin A-a nematicidal cyclododecapeptide containing nine N-methyl amino acids

摘要

Omphalotin A (Fig.1) was identified as the nematical principle from the basidiomycete Omphalotus olearius in 1997 [1].Its activity and selectivity against the plant pathogenic nematode M.incognia were found to be superior compared to the antelminthic drug ivermectin.