Modelling of protein P2 from Haemophilus influenzae:the role of surface exposed loops on MEK1-MEK2/MAPK cascade activation

摘要

The outer membrane of gram-negative bacteria contains several protiens,among which the porins play numerous biological functions in the interaction with the host;porins are involved in the activation of signal transduction pathways and in particular,in the activation of the Raf/MEK2/MAPK cascade.