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A NOVEL SURFACE EXPOSED HAEMOPHILUS INFLUENZAE PROTEIN (PROTEIN E; PE)
A NOVEL SURFACE EXPOSED HAEMOPHILUS INFLUENZAE PROTEIN (PROTEIN E; PE)
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机译:新型表面暴露的流感嗜血杆菌蛋白(蛋白E; PE)
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摘要
The present invention relates to a surface exposed protein (protein E; pE), avirulence factor, which can be detected in Haemophilus influenzae, having anamino acid sequence as described in SEQ ID NO 1, an immunogenic fragment ofsaid surface exposed protein, and a recombinant immunogenic protein (pE (A) )or truncated variants thereof based on said surface exposed protein. Nucleicacid sequences, vaccines, plasmids and phages, non human hosts, recombinantnucleic acid sequences, fusion proteins and fusion products are alsodescribed. A method of producing the said protein or truncated fragmentsthereof recombinantly is also disclosed.
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机译:本发明涉及表面暴露的蛋白质(蛋白质E; pE),一种可以在流感嗜血杆菌中检测到的毒力因子SEQ ID NO 1中所述的氨基酸序列,所述表面暴露蛋白和重组免疫原性蛋白(pE(A))或其基于所述表面暴露蛋白的截短变体。核的酸序列,疫苗,质粒和噬菌体,非人类宿主,重组核酸序列,融合蛋白和融合产物也是描述。产生所述蛋白质或截短片段的方法还公开了其重组。
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