Evidence for the presence of a secondary binding site between HIV-MN-gp120 PND and the CD4 CDR3 region

摘要

The entry of human immunodficiency virus (HIV) into target cells requires the interaction of the viral exterior envelope glycoprotein,gp120,with CD4 and a chemokine receptor on the cell surface [1].The HIV-1 gp120 binding site has been mapped to the Ig-CDR2-like region of CD4 first domain [2].A second area of this domain,named Ig-CDR-3-like region (amino acids 81-96),has been shown to be involved in gp120-CD4 interctions,but its gp120 counterpart remained so far unknown [3].