EVALUATION OF IMMUNE RESPONSE INDUCED BY ATTENUATED AND WILD-TYPE PRRS VIRUS

摘要

Porcine reproductive and respiratory syndrome virus (PRRSV) modified-live vaccines (MLV) have been developed by attenuation in cell culture. Under experimental conditions the vaccines are efficacious; however, under field conditions vaccine efficacy reports have ranged from excellent to poor. One possible reason for questionable efficacy is that MLV may not induce a similar immune response when compared to wild-type PRRSV infection. The goal of the study reported here was to compare the cellular immune response in pigs following exposure to an attenuated PRRSV or its wild-type parent virus.