Primary Study of an Injectable In Situ Composite of Collagen/Calcium Phosphate Porous Scaffold for Bone Substitute

摘要

This study was to develop an injectable biocompatible and porous calcium phosphate collagen composite cement scaffold by in situ setting. TTCP was prepared as main material of the CPC powder, and the collagen solution was added into the phosphoric acid directly to form the liquid phase. The injectable time (t{sub}I), setting time (t{sub}S) and setting temperature (T{sub}S), along with the PH value were recorded during the setting process. The compressive strength, morphology and porosity were tested. With the increase of collagen, this novel CPC get a t{sub}I of 5mins to 8mins, t{sub}S of 20mins to 30mins, compressive strength from 1.5MPa to 4MPa, and the porosity from 40% to 60%. This study gave a possibility to form a porous scaffold of collagen/CPC composite with the nature of injectability and setting in situ.