INJECTABLE, SELF-HARDENING AND POROUS CALCIUM PHOSPHATE BONE GRAFT SUBSTITUTE AND ADDITIVE INDUCING MACRO-PORES IN HARDENING

摘要

The present invention relates to a self-hardening porous bone graft capable of injecting calcium phosphate and a method for applying an additive for generating macropores , the self-hardening porous bone graft which contains bead type -tricalcium phosphate as a main ingredient and in which macropores and micropores, as available places for tissue growth and new bone delivery into the bone graft after the bone graft is treated and the same is hardened, are placed so that the porosity is more than 50% and the method for applying an additive for generating the macropores. The calcium phosphate-injectable bone graft powder of the prevent invention for accomplishing the goal comprises -tricalcium phosphate, monocalcium phosphate monohydrate, and Sodium pyrophosphate dibasic. The calcium phosphate-injectable bone graft of the prevent invention, composed of the same, which is a calcium phosphate based ceramic bone graft containing the bead a certain ratio and has high injectivity and biodegradability after transplant. Also, since a method for manufacturing an injection solution using the bone graft and the bone graft mixed with a kit for manufacturing the same has a high fluidity right after injection, the bone graft can be easily transferred into the injection instrument like a syringe and can be effectively injected into any site of a body within 5 minutes of mixing. And also, since the bone graft has macropores of 50 um in diameter as a bone graft comprising dicalcium phosphate dihydrate or calcium phosphate, dibasic and -tricalcium phosphate after hardening, the macropores which are available places for tissue growth and new bone delivery are effectively provided.