FABRICATING METHOD OF POROUS CALCIUM-PHOSPHATE BONE SUBSTITUTE MATERIAL AND POROUS CALCIUM-PHOSPHATE BONE SUBSTITUTE MATERIAL FABRICATED THEREBY

摘要

The present invention relates to a calcium phosphate based microparticles having a microsized pore structure and a method for manufacturing the same and, more specifically, a method for manufacturing microparticles by manufacturing particles with nanoparticles manufactured by using a polymer as a template and polymer mixed liquid, then manufacturing porous particles which are 800-1200 m in size by high temperature heating. The size and degrading level of the porous microparticles according to the present invention can be controlled by controlling the concentration of the liquid, reaction time, and the temperature of the heat. Also, since the porous microparticles according to the present invention has an excellent bioactivity, not only as a drug carrier, the porous microparticles induce the formation of apatite, a component similar to human bones, thereby being widely used as a material for a bone filling, a restoration material, and a supporter. [Reference numerals] (AA) Making and mixing water soluble polymer liquid and calcium ion precursor solution; (BB) 0.1N Hydrochloric acid or 0.1N ammonia; (CC) Dropping phosphate ion precursor solution; (DD) Reacting for 24 hours; (EE) Synthesizing hydroxyapatite inorganic particles; (FF) Centrifuging and drying; (GG) Mixture of phosphate ion precursor solution, water soluble polymer, and inorganic particles; (HH) Bridging reacting for 24 hours after dropped into calcium ion precursor solution; (II) Manufacturing porous bone substitute particles