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Modelling of Droplet Absorption and Evaporation during Pharmaceutical Tablet Coating

机译:药剂片涂层液滴吸收和蒸发的建模

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The shelf life of a pharmaceutical tablet is affected by the amount of water that interacts with it during the aqueous film coating process. The purpose of this work is to simulate the spreading, absorption and evaporation of water droplets after impact on a porous tablet core. We divided the spreading, absorption and evaporation phenomena into three separate phases: the kinematic, the capillary and the evaporation phases. For the kinematic phase, we modified 1-D spreading models found in the literature which solve the kinetic energy balance equation. Subsequently, for the capillary phase we solved the Navier-Stokes equation using the lubrication approximation theory. For the evaporation phase, we developed a novel model that treats the tablet as a particle with a wet core surrounded by a dry crust. Our numerical results were in good agreement with recent experimental data found in the literature.
机译:药物片剂的保质期受水膜涂布过程中与其相互作用的水量的影响。这项工作的目的是模拟在撞击多孔片剂核心后的水滴的扩散,吸收和蒸发。我们将传播,吸收和蒸发现象分为三个单独的阶段:运动学,毛细管和蒸发阶段。对于运动阶段,我们修改了在文献中发现的1-D播种模型,该模型解决了动能平衡方程。随后,对于毛细管阶段,我们使用润滑近似理论解决了Navier-Stokes方程。对于蒸发阶段,我们开发了一种新型模型,该模型将片剂作为颗粒作为颗粒,湿芯被干燥的外壳包围。我们的数值结果与文献中的最近发现的实验数据一致。

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