Population balance modeling of influenza virus replication in MDCK cells during vaccine production

摘要

In this contribution a population balance model of influenza A virus replication during vaccine production in Madin-Darby canine kidney (MDCK) cell cultures is developed. Differentiation on the population level is described by a degree of infection, which is proportional to the amount of intracellular viral proteins. This can be measured directly using flow cytometry. It is shown that the model shows reasonable agreement with experimental data, although not all details of the inner dynamics can be fully reproduced.