Antithrombotic and proangiogenic effects of sulphated polysaccharides from marine origin

摘要

Fucoidans are polysaccharides with high antithrombotic activities, low anticoagulant effect and thus low haemorrhagic risk in rabbit. Theyinhibit smooth muscle cell proliferation (Logeart et al., 1997) which is a crucial step in the formation of atherosclerotic lesions, and exhibit an in vitro proangiogenic effect. They are thus potential promising antithrom-botic drugs which could be of interest in preventing restenosis or potentiating neovascularization of ischaemic areas.