Hematin (hydroxyferriprotoporphyrin) is the stable, oxidized form of the free heme center of the enzyme, horseradish peroxidase (HRP). In comparison to HRP, hematin (HEM) is an inexpensive iron-porphyrin molecule that does not contain any amino acid residues and hence has significantly higher stability in a wider range of pH conditions. We report here the development of a specifically modified hematin with tethered polyethylene glycol (PEG) chains for use as a biocatalyst in our template assisted, enzymatic synthetic approach. This novel synthetic enzyme or syn-enzyme can serve as an effective alternative to HRP for the synthesis of polyaniline and polyphenol. The conductivity and spectroscopy of polyaniline and polyphenol synthesized by this PEG-hematin in the presence of the template, polystyrene sulfonate is presented.
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