Design and synthesis of a selective PSA cleavable peptide-doxorubicin prodrug which targets PSA positive tumor cells

摘要

Prostate cancer is the second leading cause of cancer mortality in males.It is estimated that 37,000 men died of prostate carcinoma in the United States in 1999.While cancer that is confined to the prostate can be treated with surgery or radiation,the prognosis for metastatic disease is poor.