Mimicry of the backbone and side-chain geometry of peptide turns:synthesis of novel 4-substituted indolizindin-9-one amino acids

摘要

Indolizidinone amino acids have served as beta-rurn mimics for exploring conformation-activity relationships in natural peptides.Focus has been paricularly placed ton mimicry of peptides containing aromatic residues within turn regions because of their importance in various recognition events.